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이종국 교수[Lee, Jongkook]
jkl@kangwon.ac.kr
033)250-6924
약품제조화학
약품화학
· 2001. 04 ~ 2001. 12: Korea Institute of Science & Technology, Post-doc.
· 2002. 01 ~ 2004. 04: Imagene Co., Ltd., Senior Researcher
· 2004. 06 ~ 2007. 04: The Scripps Research Institute, Post-doc.
· 2007. 05 ~ 2012. 02: Korea Research Institute of Chemical Technology, Senior Researcher
· 2011. 03 ~ 2012. 02: University of Science & Technology in Korea, Assistant Professor
· 2012. 03 ~ present: Kangwon National University, College of Pharmacy, Assistant Professor
· 1991. 03 ~ 1995. 02: Seoul National University (B.S.-Manufacturing Pharmacy)
· 1995. 03 ~ 1997. 02: Seoul National University (M.S.-Pharmaceutical Chemistry)
· 1997. 03 ~ 2001. 02: Seoul National University (Ph.D.-Pharmaceutical Chemistry)
· Discovery of cellular signal transduction regulators
· Total synthesis of biologically active natural products
· Development of synthetic methodologies
*Corresponding author

1. Sun-Young Han, Chong Ock Lee, Sung-Hoon Ahn, Mi-Ok Lee, So-Young Kang, Hyuk-Jin Cha, Sung Yun Cho, Jae Du Ha, Jae Wook Ryu, Heejung Jung, Hyoung Rae Kim, Jong Sung Koh, Jongkook Lee,* Evaluation of a Multi-kinase Inhibitor KRC-108 as an Anti-tumor Agent in Vitro and in Vivo, Invest. New Drugs 2012, 30, 518-523.

2. Jeong In Yun, Hyoung Rae Kim, Sang Kyum Kim, Deukjoon Kim, Jongkook Lee,* Cross-metathesis of allyl halides with olefins bearing amide and ester groups, Tetrahedron 2012, 68, 1177-1184.

3. Jae Wook Ryu, Sun-Young Han, Jeong In Yun, Sang-Un Choi, Heejung Jung, Jae Du Ha, Sung Yun Cho, Chong Ock Lee, Nam Sook Kang, Jong Sung Koh, Hyoung Rae Kim, Jongkook Lee,* Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors, Bioorg. Med. Chem. Lett. 2011, 21, 7185-7188.

4. Tae-Gyu Nam, Jongkook Lee, John R. Walker, Achim Brinker, Charles Y. Cho, Peter G. Schultz,* Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin, ChemMedChem 2011, 6, 777-780.

5. Jongkook Lee, Seung-Mann Paek, Sun-Young Han,* FMS-like tyrosine kinase 3 inhibitors: a patent review, Expert. Opin. Ther. Pat. 2011, 21, 483-503.

6. Jeong In Yun, Deukjoon Kim, Jongkook Lee,* Cross-metathesis of allyl halides with olefins bearing an alpha-alkoxy amide group, Tetrahedron Lett. 2011, 52, 1928-1930.

7. Byungsook Kim, Te-ik Sohn, Sanghee Kim, Deukjoon Kim,* Jongkook Lee, Concise Substrate-Controlled Asymmetric Total Synthesis of (+)-3-(Z)-Dihydrorhodophytin, Heterocycles, 2011, 82, 1113-1118 (Special Issue for Prof. A. Eschenmoser).

8. Sung Yun Cho, Sun-Young Han, Chong Ock Lee, Jae Wook Ryu, Heejung Jung, Jae Du Ha, Namsook Kang, Hyoung Rae Kim, Jong Sung Koh, Jongkook Lee,* Discovery of benzoxazoles as orally active c-Met kinase inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, 4223-4227.

9. Jongkook Lee, Jiyong Hong, Tae-Gyu Nam, Eric C. Peters, Anthony P. Orth, Bernhard H. Geierstanger, Lawrence E. Goldfinger, Mark H. Ginsberg, Charles Y. Cho, Peter G. Schultz,* A Small Molecule Inhibitor of alpha4 Integrin-Dependent Cell Migration Bioorg. Med. Chem. 2009, 17, 977-980 (Special Issue for Prof. J. A. Ellman).

10. Lubica Supekova, Frantisek Supek, Jongkook Lee, Shawn Chen, Nathanael Gray, John P. Pezacki, Peter G. Schultz,* Identification of human kinases required for HCV replication by siRNA library screening J. Biol. Chem. 2008, 283, 29-36.

11. Jongkook Lee, Xu Wu, Marina Pasca di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y. Cho, Peter G. Schultz,* A Small Molecule Antagonist of Sonic Hedgehog Signaling Pathway, ChemBioChem, 2007, 8, 1916-1919.

12. Jiyong Hong, Jongkook Lee, Kyung-Hoon Min, John R. Walker, Nathanael S. Gray, Charles Y. Cho, Peter G. Schultz,* Identification and Characterization of Small Molecule Inducers of Epidermal Keratinocyte differentiation, ACS: Chemical Biol. 2007, 2, 171-175.

13. Miyun Kwon, Hyun-Jin Kim, Jongkook Lee, Jaehoon Yu,* Enhanced Binding Affinity of Neomycin-Chloramphenicol (or Linezolid) Conjugates to A-Site Model of 16S Ribosomal RNA, Bull. Korean Chem. Soc. 2006, 27, 1664-1666.

14. Jongkook Lee,* Jiyong Hong, First Synthesis and Structural Elucidation of (-)-Presphaerene J. Org. Chem. 2004, 69, 6433-6440.

15. Sun-Young Jang, Young Hwan Ha, Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee,* Hyun-Joon Ha,* Bioorg. Med. Chem. Lett. 2004, 14, 3881-3883.

16. Jongkook Lee, Miyun Kwon, Kyoung Hyun Lee, Sunjoo Jeong, Soon-Sil Hyun, Kye Jung Shin, Jaehoon Yu,* An Approach to Enhance Specificity Against RNA Targets Using Hetero-Dimeric Conjugates of Aminoglycosides and Chloramphenicol (or Linezolid), J. Am. Chem. Soc. 2004, 126,1956-1957.

17. Jin-Hwan Kwak,* Hyunjoo Kim, Minjung Sul, Byungsun Seo, Jongkook Lee, Sooyoung Choi, 세균의 Peptide Deformylase(PDF)를 억제하는 새로운 항균물질의 스크리닝, Yakhakhoeji 2003, 47, 184-189.

18. Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim Deukjoon Kim,* Efficient construction of bicyclic system by internal SN2' enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of trans-hydrindane nucleus Tetrahedron Lett. 2003, 44, 7043-7044.

19. Deukjoon Kim,* Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Takauki Doi, Sanghee Kim, Role of Conformational Effects on the Regioselectivity of Macrocyclic INOC Reactions: Two New Asymmetric Total Synthesis of (+)-Brefeldin A J. Org. Chem. 2002, 67,772-781.

20. Deukjoon Kim,* Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Hyunil Jo, Sanghee Kim, Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition, J. Org. Chem. 2002, 67, 764-771.

21. DeukjoonKim,* Jongkook Lee, Jiyoung Chang, Sanghee Kim, Stereoselective synthesis of (±)-beta-elemene by a doubly diastereodifferentiating internal alkylation: a remarkable difference in the rate of enolization between synandantiesters, Tetrahedron 2001, 57, 1247-1252.

22. Deukjoon Kim,* Phil Jong Shim, Jongkook Lee, Cheo lWon Park, Sung Woo Hong, Sanghee Kim, Construction of the Tricyclo[5.3.1.01,5]undecane System by a Novel Tandem Pinacol Rearrangement-Ene Strategy: A Formal Total Synthesis of (±)-Perhydrohistrionicotoxin, J. Org. Chem. 2000, 65, 4864-4870.