강원대학교 약학대학
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고현정 교수[Ko, Hyun-Jeong]
종양면역 / 감염면역 / 백신개발
· 2005. 09 ~ 2008. 08 서울대학교 약학대학 종합약학연구소 - 선임 연구원
· 2007. 05 ~ 2008. 12 국제백신연구소 - Visiting Scientist & Post-doctoral Fellow
· 2008. 12 ~ 2010. 03 BWH, 하버드 의대 - Research Fellow
· 2010. 03 ~ 현재 국제백신연구소 - Visiting Scientist
· 2010. 03 ~ 현재 강원대학교 약학대학 약학과 조교수
· 1995 ~ 1999 서울대학교 약학대학 약학과 - 학사
· 1999 ~ 2001 서울대학교 약학대학 제약학과 (미생물약품화학-면역학) - 석사
· 2001 ~ 2005 서울대학교 약학대학 제약학과 (미생물약품화학-면역학) - 박사
· Immunotherapy against cancer and infectious disease
· Development of vaccine and adjuvant
· In vivo mechanistic study of crosstalk between adaptive and innate immunity
· ER stress and autophagy in antigen presenting cells
Lee JM, Kim EK, Seo H, Jeon I, Chae MJ, Park YJ, Song B, Kim YS, Kim YJ, Ko HJ, Kang CY.
Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation.
Eur J Immunol. 2014. In press.

Chang SY, Ko HJ, Kweon MN.
Mucosal dendritic cells shape mucosal immunity.
Exp Mol Med. 2014. 46:e84.

Song J, Yeo SG, Hong EH, Lee BR, Kim JW, Kim J, Jeong H, Kwon Y, Kim H, Lee S, Park JH, Ko HJ.
Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a.

Biomol Ther (Seoul). 2014. 22:41-6.

Kim YJ, Yeo SG, Park JH, Ko HJ.
Shigella vaccine development: prospective animal models and current status.
Curr Pharm Biotechnol. 2014. 14:903-12.

Chang SY, Lee SN, Yang JY, Kim DW, Yoon JH, Ko HJ, Ogawa M, Sasakawa C, Kweon MN.
Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model.
PLoS One. 2013. 8:e81095.

Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Kim JS, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ.
Effect of Codonopsis lanceolata with Steamed and Fermented Process on Scopolamine-Induced Memory Impairment in Mice.
Biomol Ther (Seoul). 2013. 21:405-10.

Weon JB, Ko HJ, Ma CJ.
The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.
Bioorg Med Chem Lett. 2013. 23:6732-6.

*Adolph TE, *Tomczak MF, *Niederreiter L, *Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, *Kaser A, *Blumberg RS.
Paneth cells as a site of origin for intestinal inflammation.
Nature. 2013. 503:272-6. (*Equally contributed)

Yang JY, Lee SN, Chang SY, Ko HJ, Ryu S, Kweon MN.
A Mouse Model of Shigellosis by Intraperitoneal Infection.
J Infect Dis. 2014. 209:203-15.

Hong EH, Chang SY, Lee BR, Kim YS, Lee JM, Kang CY, Kweon MN, Ko HJ.
Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells.
Int J Cancer. 2013. 132:2839-48.

Hong EH, Chang SY, Lee BR, Pyun AR, Kim JW, Kweon MN, Ko HJ.
Intratumoral injection of attenuated Salmonella vaccine can induce tumor microenvironmental shift from immune suppressive to immunogenic.
Vaccine. 2013. 31:1377-84.

Yang H, Ko HJ, Yang JY, KimJJ, Seo SU, Park SG, Choi SS, Seong JK, Kweon MN.
Interleukin-1 promotes coagulation, which is necessary for protective immunity in the lung against Streptococcus pneumoniae infection.
J Infect Dis. 2013. 207:50-60.

Ko HJ, Oh SK, Jin JH, Son KH, Kim HP.
Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica.
Biomol Ther (Seoul). 2013. 21:66-71.

Chang SY, Kim YJ, Ko HJ.
Potential therapeutic anti-tumor effect of a Salmonella-based vaccine.
Hum Vaccin Immunother. 2013. 9:1654-1660.

Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Kim JS, Lee HY, Park DS, Chung HC, Chung JY and Ma CJ.
Effect of Codonopsis lanceolata with Steamed and Fermented Process on Scopolamine-Induced Memory Impairment in Mice.
Biomol Ther (Seoul). 2013. 21: 405-410

Kim SJ, Hong EH, Lee BR, Park MH, Kim JW, Pyun AR, Kim YJ, Chang SY, Chin YW, Ko HJ.
Alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation.
Immune Netw. 2012. 12:253-60.

*Ko HJ, *Yang H, Yang JY, Seo SU, Chang SY, Seong JK, Kweon MN.
Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient mice.
Eur J Immunol. 2012. 42:618-28. (*Equally contributed)

Kim YS, Kim YJ, Lee JM, Kim EK, Park YJ, Choe SK, Ko HJ, Kang CY.
Functional changes in myeloid-derived suppressor cells (MDSCs) during tumor growth: FKBP51 contributes to the regulation of the immunosuppressive function of MDSCs.
J Immunol. 2012. 188:4226-34.

Lee JM, Seo JH, Kim YJ, Kim YS, Ko HJ, Kang CY.
The restoration of myeloid-derived suppressor cells as functionalantigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment.
Int J Cancer. 2012. 131:741-51.

Cha HR, Ko HJ, Kim ED, Chang SY, Seo SU, Cuburu N, Ryu S, Kim S, Kweon MN.
Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control.
J Immunol. 2011. 187:3044-52.

Chang JH, Cha HR, Chang SY, Ko HJ, Seo SU, Kweon MN.
IFN-gamma secreted by CD103+ dendritic cells leads to IgG generation in themesenteric lymph node in the absence of vitamin A.
J Immunol. 2011. 186:6999-7005.

Seo SU, Kwon HJ, Ko HJ, Byun YH, Seong BL, Uematsu S, Akira S, Kweon MN.
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice.
PLoS Pathog. 2011. 7:e1001304.

Kim YJ, Han SH, Kang HW, Lee JM, Kim YS, Seo JH, Seong YK, Ko HJ, Choi TH, Moon C, Kang CY.
NKT ligand-loaded, antigen-expressing B cells function as long-lasting antigen presenting cells in vivo.
Cell Immunol. 2011. 270:135-44.

Ko HJ, Jin JH, Kwon OS, Kim JT, Son KH, Kim HP.
Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica
Biomol Ther (Seoul). 2011. 19:324-330

Kim YS, Kim YJ, Lee JM, Han SH, Ko HJ, Park HJ, Pereboev A, Nguyen HH, Kang CY.
CD40-targeted recombinant adenovirus significantly enhances the efficacy of antitumor vaccines based on dendritic cells and B cells.
Hum Gene Ther. 2010. 21(12):1697-706.

Lee JM, Seo JH, Kim YJ, Kim YS, Ko HJ, Kang CY.
Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b+Gr-1+ Myeloid-derived Suppressor Cells.
Immune Netw. 2010. 10:104-8.

Shim DH, Ko HJ, Volker G, Potter AA, Mutwiri G, Babiuk LA, Kweon MN.
Efficacy of poly[di(sodium carboxylatophenoxy)phosphazene] (PCPP) as mucosal adjuvant to induce protective immunity against respiratory pathogens.
Vaccine. 2010. 28:2311-7.

Chang SY, Cha HR, Ko HJ, Yang HJ, Malissen B, Iwata M and Kweon MN.
Lack of retinoic acid leads to expansion of langerin-expressing dendritic cells in gut-associated lymphoid tissues.
Gastroenterology. 2010. 138:1468-78.

Ko HJ, Yang JY, Shim DH, Yang H, Park SM, AkiraS, Curtiss IIIR, Kweon MN.
Innate immunity mediated by MyD88 signal is not essential for induction of LPS-specific B cell responses but is indispensable for protection against Salmonella typhimurium infection.
J Immunol. 2009. 182:2305-12.

Ko HJ, Lee JM, Kim YJ, Kim YS, Lee KA, Kang CY.
Immunosuppressive MDSCs can be converted into immunogenic APCs with the help of activated NKT cells; an alternative cell-based anti-tumor vaccine.
J Immunol. 2009. 182:1818-28.

Park SM, Ko HJ, Shim DH, Yang JY, Park YH, Curtiss III R, Kweon MN.
MyD88 Signaling Is Not Essential for Induction of Antigen-Specific B Cell Responses but Is Indispensable for Protection Against Streptococcus pneumoniae Infection following Oral Vaccination with Attenuated Salmonella Expressing PspA Antigen.
J Immunol. 2008. 181:6447-55.

Ko HJ, Kim YJ, Kim YS, Kim JM, Ho SH, Jeong JG, Oh SM, Chae JA, Kim CY, Lee PS, Kang CY.
Immunogenicity and safety profiles of genetic vaccines against human Her-2/neu in cynomolgus monkeys.
Gene Therapy. 2008. 15:1351-60.

Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY.
A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.
Cell Immunol. 2008. 251:50-55.

Kim YJ, Ko HJ, Kim YS, Kim DH, Kang S, Kim JM, Chung Y, Kang CY.
alpha-Galactosylceramide-loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity.
Int J Cancer. 2008. 122:2774-2283.

Ko HJ, Kim YJ, Kim YS, Chang WS, Ko SY, Chang SY, Sakaguchi S, Kang CY.
A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model.
Cancer Res. 2007. 67:7477-7486.

Ko SY, Lee KA, Youn HJ, Kim YJ, Ko HJ, Heo TH, Kweon MN, Kang CY.
Mediastinal lymph node CD8alpha- DC initiate antigen presentation following intranasal coadministration of alpha-GalCer.
Eur J Immunol. 2007. 37:2127-2137.
Youn HJ, Ko SY, Lee KA, Ko HJ, Lee YS, Fujihashi K, Boyaka P, Kim SH, Horimoto T, Kweon MN, Kang CY.
A single intranasal immunization with inactivated influenza virus and a-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system.
Vaccine. 2007. 25:5189-5198.

Chung Y, Kim BS, Kim YJ, Ko HJ, Ko SY, Kim DH, Kang CY.
CD1d-restricted T cells license B cells to generate long-lasting cytotoxicantitumor immunity in vivo. Cancer Res. 2006. 66:6843-6850.

Ko SY, Ko HJ, Chang WS, Kweon MN, Park SH, Kang CY.
(Alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor.
J. Immunol. 2005. 175:3309-3317.

Ko HJ, Ko SY, Kim YJ, Lee EG, Cho SN, Kang CY.
Optimization of Codon Usage Enhances the Immunogenicity of a DNA Vaccine Encoding Mycobacterial Antigen Ag85B.
Infect. Immun. 2005. 73:5666-5674.

Chung Y, Ko SY, Ko HJ, Kang CY.
Split peripheral tolerance: CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens.
Eur. J. Immunol. 2005. 35:1381-1390.

Chang SY, Ko HJ, Heo TH, Kang CY.
Heparan sulfate regulates the antiangiogenic activity of endothelial monocyte-activating polypeptide-II at acidic pH.
Mol. Pharmacol. 2005. 67:1534-1543.

Chang SY, Lee KC, Ko SY, Ko HJ, Kang CY.
Enhanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants.
Int. J. Cancer. 2004. 111:86-95.

Baek KM, Ko SY, Lee M, Lee JS, Kim JO, Ko HJ, Lee JW, Lee SH, Cho SN, Kang CY.
Comparative analysis of effects of cytokine gene adjuvants on DNA vaccination against Mycobacterium tuberculosis heat shock protein 65.
Vaccine. 2003. 21:3684-3689.