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신은주 교수[Shin, Eun-Joo]
shinej@kangwon.ac.kr
033)250-6922
신경약리학Ⅱ
행동약리학 / 신경약리학
· 2004-2005, 나고야대학교 의학대학원 박사후 연구원
· 2006-2007, 강원대학교 BK21 신경보호제개발 인력양성팀 박사후 연구원
· 2014.3-현재, 강원대학교 약학대학 약학과 부교수
· 1998, Kangwon National University (B.S. - Pharmacy)
· 2000, Kangwon National University Graduate School (M.S. - Neuropharmacology & Toxicology)
· 2003, Kangwon National University Graduate School (Ph.D. - Neuropharmacology & Toxicology)
· Behavioral pharmacology of neurodegenerative disease and drug dependence
· Development of in vivo animal models for neurodegenerative diseases
· In vivo mechanistic study of novel neuroprotectant
Kim HC, Bing G, Jhoo WK, Kim WK, Shin EJ, Im DH, Kang KS, Ko KH. Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. Life Sci. 2003; 72(7): 769-783.

Kim HC, Shin CY, Seo DO, Jhoo JH, Jhoo WK, Kim WK, Shin EJ, Lee YH, Lee PH, Ko KH.New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. Life Sci. 2003; 72(16): 1883-1895.

Kim HC, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo WK, Im DH, Shin EJ, Hjelle OP, Ottersen OP, Park SC, Kato K, Mirault ME, Nabeshima T. Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo. Neuroscience. 2003; 119(2): 399-419.

Kwon YS, Park DH, Shin EJ, Kwon MS, Ko KH, Kim WK, Jhoo JH, Jhoo WK, Wie MB, Jung BD, Kim HC.Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neurosci Lett. 2004; 355(3): 231-235.

Kwon YS, Ann HS, Nabeshima T, Shin EJ, Kim WK, Jhoo JH, Jhoo WK, Wie MB, Kim YS, Jang KJ, Kim HC.Selegiline potentiates the effects of EGb 761 in response to ischemic brain injury.Neurochem Int. 2004; 45(1): 157-170.

Shin EJ, Nah SY, Kim WK, Ko KH, Jhoo WK, Lim YK, Cha JY, Chen CF, Kim HC.The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005; 144(7): 908-918.

Kwon YS, Nabeshima T, Shin EJ, Chun W, Jhoo JH, Jhoo WK, Wie MB, Jang CG, Chung H, Sung YE, Kim HC.PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. Biol Pharm Bull. 2004; 27(6): 906-909.

Shin EJ, Nabeshima T, Lee PH, Kim WK, Ko KH, Jhoo JH, Jhoo WK, Cha JY, Kim HC. Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behav Brain Res. 2004; 151(1-2): 267-276.

Shin EJ, Jhoo JH, Kim WK, Jhoo WK, Lee C, Jung BD, Kim HC. Protection against kainate neurotoxicity by pyrrolidine dithiocarbamate. Clin Exp Pharmacol Physiol. 2004; 31(5-6): 320-326.

Jhoo JH, Kim HC, Nabeshima T, Yamada K, Shin EJ, Jhoo WK, Kim W, Kang KS, Jo SA, Woo JI. Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav Brain Res. 2004; 155(2): 185-196.

Shin EJ, Oh KW, Kim KW, Kwon YS, Jhoo JH, Jhoo WK, Cha JY, Lim YK, Kim IS, Kim HC. Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia root extract. Life Sci. 2004; 75(23): 2751-2764.

Shin EJ, Nabeshima T, Suh HW, Jhoo WK, Oh KW, Lim YK, Kim DS, Choi KH, Kim HC.Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression. Behav Brain Res. 2005; 158(1): 143-157.

Shin EJ, Suh SK, Lim YK, Jhoo WK, Hjelle OP, Ottersen OP, Shin CY, Ko KH, Kim WK, Kim DS, Chun W, Ali S, Kim HC.Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis. Neuroscience. 2005; 133(3): 715-727.

Shin EJ, Jhoo JH, Nabeshima T, Jhoo WK, Kwon MS, Lim YK, Chae JS, Jung ME, Park SJ, Jang KJ, Kim HC. Growth hormone releaser attenuates beta-amyloid (1 - 42)-induced memory impairment in mice. J Pharmacol Sci. 2005; 99(1):117-120.

Kim HC, Shin EJ, Jang CG, Lee MK, Eun JS, Hong JT, Oh KW. Pharmacological action of Panax ginseng on the behavioral toxicities induced by psychotropic agents. Arch Pharm Res. 2005; 28(9): 995-1001.

Enomoto T, Noda Y, Mouri A, Shin EJ, Wang D, Murai R, Hotta K, Furukawa H, Nitta A, Kim HC, Nabeshima T.Long-lasting impairment of associative learning is correlated with a dysfunction of N-methyl-D-aspartate-extracellular signaling-regulated kinase signaling in mice after withdrawal from repeated administration of phencyclidine. Mol Pharmacol. 2005; 68(6): 1765-1774.

Liu M, Sun A, Shin EJ, Liu X, Kim SG, Runyons CR, Markesbery W, Kim HC, Bing G. Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Eur J Neurosci. 2006; 23(8): 2027-2034.

Lee JH, Shin EJ, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Lee PH, Kim HC, Nah SY. Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2006; 536(1-2):5-92.

Zhang W, Shin EJ, Wang T, Lee PH, Pang H, Wie MB, Kim WK, Kim SJ, Huang WH, Wang Y, Zhang W, Hong JS, Kim HC. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB J. 2006; 20(14): 2496-2511.

Shin EJ, Chae JS, Jung ME, Bing G, Ko KH, Kim WK, Wie MB, Cheon MA, Nah SY, Kim HC. Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor. Epilepsy Res. 2007; 73(3): 292-298.

Shin EJ, Nah SY, Chae JS, Bing G, Shin SW, Yen TP, Baek IH, Kim WK, Maurice T, Nabeshima T, Kim HC. Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.Neurochem Int. 2007; 50(6): 791-799.

Lee JH, Shin EJ, Jeong SM, Lee BH, Yoon IS, Lee JH, Choi SH, Kim YH, Pyo MK, Lee SM, Chae JS, Rhim H, Oh JW, Kim HC, Nah SY. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. Eur J Pharmacol. 2007; 564(1-3): 7-17.

Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T, Kim HC. Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J Pharmacol Sci. 2007; 105(4): 367-371.

Shin EJ, Lee PH, Kim HJ, Nabeshima T, Kim HC.Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. J Pharmacol Sci. 2008; 106(1): 22-27.

Shin EJ, Jeong JH, Bing G, Park ES, Chae JS, Yen TP, Kim WK, Wie MB, Jung BD, Kim HJ, Lee SY, Kim HC. Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice. Cell Signal. 2008; 20(4): 645-658.

Shin EJ, Ko KH, Kim WK, Chae JS, Yen TP, Kim HJ, Wie MB, Kim HC. Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats. Neurochem Int. 2008; 52(6): 1134-1147.

Shin EJ, Jeong JH, Kim AY, Koh YH, Nah SY, Kim WK, Ko KH, Kim HJ, Wie MB, Kwon YS, Yoneda Y, Kim HC. Protection Against Kainate Neurotoxicity By Ginsenosides: Attenuation Of Convulsive Behavior, Mitochondrial Dysfunction, and Oxidative Stress. J Neurosci Res. In press