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박해일 교수[Haeil Park]
haeilp@kangwon.ac.kr
033)250-6920
의약품화학
Drug Design / 구조-활성 상관관계연구 / 노인성질환 치료제개발(당뇨/치매)
· 1995~96 University of Montreal, Dept. of Chemistry, Post-Doc
· 1996~98 University of Kentucky, Dept. of Medicinal Chemistry, Post-Doc
· 2007 ~ 2009, 약학대학장
· 1981, Seoul National University (B.S. - Pharmacy)
· 1983, Seoul National University ( M.S. - Medicinal Chemistry)
· 1995, University of Kansas, USA ( Ph.D.- Medicinal Chemistry)
· Drug Design
· Structure- Activity, Relationship Study of Biologically Active Cornpounds
· Asymmetric Synthetic
· Development of Synthetic Methodology
· Anti- inflammatory Agento
*Corresponding author

"3-(4-(tert-Octyl)phenoxy)propane-1,2-diolsuppressesinflammatoryresponsesviainhibitionofmultiplekinases" Biochemical Pharmacology 22, 1540~1551 (2012)*

"OroxylinA analogs exhibited strong inhibitory activities againstiNOS-mediated nitricoxide(NO)production" Bioorganic & Medicinal Chemistry Letters, 22, 2534~2535 (2012)*

"The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice" Eur. J. Pharmacology 689, 104~110 (2012)

"Synthesis of chrysin analogs with a heteroaryl group and evaluation for their anti-inflammatory activities" Yakhak Hoeji 55, 462~465 (2011)*

"Newsyntheticanti-inflammatorychrysinanalog,5,7-dihydroxy-8-(pyridine-4-yl)flavone" Eur.J. Pharmacology 670, 617~622 (2011)

"AchrysinanalogexhibitedstronginhibitoryactivitiesagainstbothPGE2andNOproduction" Eur.J.MedicinalChemistry 46, 4657~4660 (2011)*

"EffectsofFlavonoidsonMatrixMetalloproteinase-13ExpressionofInterleukin-1beta-TreatedArticularChondrocytesandTheirCellularMechanisms:Inhibitionofc-Fos/AP-1andJAK/STATSignalingPathways" JournalofPharmacologicalSciences 116, 221~231 (2011)

"SynthesisandCharacterizationofNovelUnnaturalBichalcones(ChalconeDimers)" Arch.Pharm.Res. 33, 1919~1926 (2010)*

"1,5-DiarylimidazoleswithstronginhibitoryactivityagainstCOX-2catalyzedPGE2productionfromLPS-inducedRAW264.7cells" Bioorganic&MedicinalChemistryLetters 20, 4035~4037 (2010)*

"RecentAdvancesinAnti-inflammatorySyntheticFlavonoidsasPotentialDrugs", NaturalProductSciences 16, 59~67 (2010)

"CordycepspruinosaextractsinduceapoptosisofHeLacellsbyacaspasedependentpathway" JournalofEthnopharmacology 128, 342~351 (2010)

"StructuralAlterationsofWogoninSignificantlyReducetheInhibitoryActivityagainstCOX-2CatalyzedPGE(2)ProductionfromLPS-InducedRAW264.7Cells" Biomolecules&Therapeutics 17, 418~421 (2009)*

"Newanti-inflammatorysyntheticbiflavonoidwithC-C(6-6aEuro(3))linkage:Differentialeffectsoncyclooxygenase-2andinduciblenitricoxidesynthase" Arch.Pharm.Res. 32, 1525~1531 (2009)*

"InhibitionofprostaglandinE-2productionbysyntheticWogoninanalogs" Arch.Pharm.Res. 32, 1503~1508 (2009)*

"InhibitoryactivityofprostaglandinE-2productionbythesynthetic2'-hydroxychalconeanalogues:SynthesisandSARstudy" Bioorganic&MedicinalChemistryLetters 19, 1650~1653 (2009)*

"Synthesisofbiflavoneshavinga6-O-7 linkageandeffectsoncyclooxygenase-2andinduciblenitricoxidesynthase" Bioorganic&MedicinalChemistryLetters 19, 74~76 (2009)*