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김형춘 교수[Kim, Hyoung-Chun]
kimhc@kangwon.ac.kr
033)250-6917
신경약리학Ⅰ
정신신경약리학 / 신경독성학 / Morphinan계 및 항산화 / 항염증약 물의 신경조절기전 /
뇌퇴행 (인지기능저하)지전 / 약물중독기전
· 1992.06~1993.01, 텍사스 A & M대학교 객원 연구원
· 1993.01~1994.08, NIH/NIEHS (미국)방문 연구원
· 2001.03~2003.02, 강원대학교 약학대학장
· 1989.03~현재, 강원대학교 교수
· 2007.02~2008.03, 강원대학교 종합약학 연구소장

· 1972.3~1976.2 Chung Ang University (B.S. - Pharmacy)
· 1982.3~1984.2 Chung Ang University (M.S. - Toxicology)
· 1984.3~1987.2 Chung Ang University (Ph.D. - Pharmacology)

· Role of oxidative stress in the Neuronal degeneration (including Parkinsonian, Epileptic and Alzheimer-like models)
· Behavioral alterations (including memory impairments) and Neurotoxic Mechanisms mediated by Psychotropic drugs
· Development of Novel Neuroprotectant
아세틸살리실산 말톨 에스테르(AME)를 포함하는 파킨슨병 치료용 약제학적 조성물
- 출원일자 (2008.7.23) 출원번호 10-2008-0068438

N-메틸-N-프로핀일-2-페닐에틸아민(MPPE)를 포함하는 파킨슨병 치료용 약제학적 조성물
- 출원일자 (2008.4.1) 출원번호 10-2008-0030364



치매의 개선 및 치료 효과와 인지 기억능력 향상효과를 가지는 양강추출물
- 출원일자 (2008.1.15) 출원번호 10-2008-0004352



우회전성 모르피난 유도체 및 이를 포함하는 신경보호용 조성물
- 출원일자 (2007. 3. 30) 출원번호10-2007-7007427



신규한 조성의 알츠하이머형 치매 및 파킨슨병 예방 또는 치료용 은행잎 추출물, 그리고 은행잎으로부터의 추출 및 정제 방법
- 출원일자 (2006. 4. 28) - 등록일자 (2007.5.23) 등록번호 10-0723609



우회전성 몰피난의 신경보호적 특성
- 출원일자 (2005. 6. 28) - 등록일자 (2007. 8. 24) 등록번호 10-0753984-0000



Neuroprotective properties of dextrorotaty morphinans
- 미국출원일자 (2005. 5. 13) 출원번호 PCT/IB2005/051582



신규한 몰피난 유도체
- 출원일자 (2001. 3. 14)- 등록일자 (2001. 3. 14) 출원번호 제10-2001-00131373호



셀레질린과 은행엽엑스를 함유한 치매개선제
- 출원일자 (1999. 9. 1) 출원번호 1998-003019-9



· 독성학 강의 (Toxicology Lecture) -도서출판 신일상사
· 조화로운 삶, 행복한 삶을 위한 건강학 Focus on Health 제6판 - 라이프사이언스 신경전달물질 - 기초와 임상 - 도서출판 신일상사
· Neurodegenerative disease - Molecular and Cellular Mechanisms and Therapeutic Advance - Plenum Press
· 독성학 - 녹지사
· 과학의 원리 - 소학사
남용약물의 내성 및 의존성 형성 기전연구 : 만성 텍스트로메솔판 투여로 유도되는 행동 및 세포면역반응
보건복지부

남용약물에 의해 매개되는 정신 작용성 및 신경 독성기전 : 만성 Fos-related antigen 단백의 역할
국립 보건원



Hydroxy Morphinan과 그 유도체 성분의 치료제 개발 및 제품화
녹십자(주) 제품화 연구



남용약물유도 신경독성 및 인지기능저하를 조절하는 유전자들의 역할 규명
뇌기능활용 및 뇌질환치료 기술개발 연구사업단



남용약물유도 정신 신경독성 규명 및 조절물질 개발
뇌기능활용및뇌질환치료기술개발연구사업단



남용약물 중독에서 prodynorphin 유전자의 역할 : Astaxanthin, ebselen 및 morphinan의 응용가능성
서울대학교



마약류 등의 내성 및 의존성 형성 기전 연구(Ⅱ) : 덱스트로메솔판 유도 신경면역 조절 변화에 TNF-a 및 TNF-a 수용체들의 역할과 덱스트로메골판 분자 구조 변화에 의한 항 정신작용 효과 평가
식품의약품안전청



옻나무추출물을 이용한 인지기능 개선용 건강기능식품의 개발
에이지아이(주)



기질성 뇌질환 및 인지력 강화에 대한 효력시험
유유 주식회사



Bone morphometric protein의 신경보호 효능 규명
티슈진(주)



뇌기능 장애 개선효과 및 혈소판 응집 억제효과 연구
유유 주식회사



메탐페타민 유도 의존성 및 도파민성 신경독성에 glutathione peroxidase 유전자의 역할: acetylsalicylic acid maltol ester의 응용
이화여자대학교



메탐페타민과 펜사이클리딘양화합물(펜사이클리딘 및 덱스트로메솔판)의 의존성과 신경독성 기전
한국과학재단 (국제공동연구)



경련성 독성에 cytokine 및 cyclooxygenase의 역할과 morphinan 유도체들의 신경 조절기전
한국과학재단 (특정기초연구)



남용약물유도 신경독성 및 인지기능저하를 조절하는 유전자들의 역할 규명
전북대학교



정신 흥분성 약물 유도 정신신경독성의 분자 기전 연구
한국과학재단 (국제협력연구사업)



노화동물의 뇌기능 저하로 유도된 행동양식 특성규명 및 노화억제물질 개발
한림대학교



Nagai T, Yamada K, Kim HC, Kim YS, Noda Y, Imura A, Nabeshima Y, Nabeshima T. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J. 2003; 17(1): 50-52.

Kim HC, Bing G, Jhoo WK, Kim WK, Shin EJ, Im DH, Kang KS, Ko KH. Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. Life Sci. 2003; 72(7): 769-783.

Nagai T, Yamada K, Kim HC, Kim YS, Noda Y, Imura A, Nabeshima Y, Nabeshima T. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J. 2003; 17(1): 50-52.

Kim HC, Bing G, Jhoo WK, Kim WK, Shin EJ, Im DH, Kang KS, Ko KH. Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. Life Sci. 2003; 72(7): 769-783.

Choi Y, Jin Y, Nam W, Kim HC, Kim WK. Blockade of peroxynitrite-mediated astrocyte death by manganese(III)-cyclam.Neurosci Res. 2003; 45(2): 157-161.

Kim HC, Shin CY, Seo DO, Jhoo JH, Jhoo WK, Kim WK, Shin EJ, Lee YH, Lee PH, Ko KH.New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. Life Sci. 2003; 72(16): 1883-1895.

Ha HJ, Kwon YS, Park SM, Shin T, Park JH, Kim HC, Kwon MS, Wie MB. Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures. Biol Pharm Bull. 2003; 26(4): 544-546.

Kim HC, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo WK, Im DH, Shin EJ, Hjelle OP, Ottersen OP, Park SC, Kato K, Mirault ME, Nabeshima T. Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo. Neuroscience. 2003; 119(2): 399-419.

Shin IC, Kim HC, Swanson J, Hong JT, Oh KW.Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. Pharmacology. 2003; 68(4): 183-189.

Han IO, Kim HS, Kim HC, Joe EH, Kim WK. Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells. J Neurosci Res. 2003; 73(5): 659-669. Nagai T, Yamada K, Kim HC, Noda Y, Nabeshima Y, Nabeshima T. Cognition impairment in the klotho gene mutant mice and oxidative stress. Nihon Shinkei Seishin Yakurigaku Zasshi. 2003; 23(5): 211-217.

Kwon YS, Park DH, Shin EJ, Kwon MS, Ko KH, Kim WK, Jhoo JH, Jhoo WK, Wie MB, Jung BD, Kim HC.Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neurosci Lett. 2004; 355(3): 231-235.

Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T. Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. J Neurosci. 2004; 24(9): 2212-2225.

Kwon YS, Ann HS, Nabeshima T, Shin EJ, Kim WK, Jhoo JH, Jhoo WK, Wie MB, Kim YS, Jang KJ, Kim HC.Selegiline potentiates the effects of EGb 761 in response to ischemic brain injury.Neurochem Int. 2004; 45(1): 157-170.

Choi JW, Shin CY, Yoo BK, Choi MS, Lee WJ, Han BH, Kim WK, Kim HC, Ko KH. Glucose deprivation increases hydrogen peroxide level in immunostimulated rat primary astrocytes. J Neurosci Res. 2004; 75(5): 722-731.

Lee JH, Jeong SM, Lee BH, Noh HS, Kim BK, Kim JI, Rhim H, Kim HC, Kim KM, Nah SY.Prevention of ginsenoside-induced desensitization of Ca2+-activated Cl- current by microinjection of inositol hexakisphosphate in Xenopus laevis oocytes: involvement of GRK2 and beta-arrestin I. J Biol Chem. 2004; 279(11): 9912-9921.

Shin EJ, Nah SY, Kim WK, Ko KH, Jhoo WK, Lim YK, Cha JY, Chen CF, Kim HC.The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005; 144(7): 908-918.

Kwon YS, Nabeshima T, Shin EJ, Chun W, Jhoo JH, Jhoo WK, Wie MB, Jang CG, Chung H, Sung YE, Kim HC.PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. Biol Pharm Bull. 2004; 27(6): 906-909.

Kwon YS, Koh JY, Song DK, Kim HC, Kwon MS, Choi YS, Wie MB.Danthron inhibits the neurotoxicity induced by various compounds causing oxidative damages including beta-amyloid (25-35) in primary cortical cultures.Biol Pharm Bull. 2004; 27(5): 723-726.

Shin EJ, Nabeshima T, Lee PH, Kim WK, Ko KH, Jhoo JH, Jhoo WK, Cha JY, Kim HC. Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behav Brain Res. 2004; 151(1-2): 267-276.

Shin EJ, Jhoo JH, Kim WK, Jhoo WK, Lee C, Jung BD, Kim HC. Protection against kainate neurotoxicity by pyrrolidine dithiocarbamate. Clin Exp Pharmacol Physiol. 2004; 31(5-6): 320-326.

Lee BH, Lee JH, Lee SM, Jeong SM, Yoon IS, Lee JH, Choi SH, Pyo MK, Rhim H, Kim HC, Jang CG, Lee BC, Park CS, Nah SY.Identification of ginsenoside interaction sites in 5-HT3A receptors. Neuropharmacology. 2007; 52(4): 1139-1150.

Jhoo JH, Kim HC, Nabeshima T, Yamada K, Shin EJ, Jhoo WK, Kim W, Kang KS, Jo SA, Woo JI. Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav Brain Res. 2004; 155(2): 185-196.

Shin EJ, Oh KW, Kim KW, Kwon YS, Jhoo JH, Jhoo WK, Cha JY, Lim YK, Kim IS, Kim HC. Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia root extract. Life Sci. 2004; 75(23): 2751-2764.

Ju C, Oh YJ, Han BH, Kim HS, Kim HC, Kim WK.Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes. Free Radic Biol Med. 2004; 37(8): 1160-1169.

Nabeshima T, Tran MH, Kim HC, Yamada K. Oxidative stress mechanism of amyloid -peptide-induced impairmrnt of neurotransmission and memory. Methods Find Exp Clin Pharmacol. 2004; 26: 29-31.

Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS.3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J. 2005; 19(3): 395-397.

Shin EJ, Nabeshima T, Suh HW, Jhoo WK, Oh KW, Lim YK, Kim DS, Choi KH, Kim HC.Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression. Behav Brain Res. 2005; 158(1): 143-157.

Lee SJ, Jin Y, Yoon HY, Choi BO, Kim HC, Oh YK, Kim HS, Kim WK. Ciclopirox protects mitochondria from hydrogen peroxide toxicity. Br J Pharmacol. 2005; 145(4): 469-476.

Shin EJ, Suh SK, Lim YK, Jhoo WK, Hjelle OP, Ottersen OP, Shin CY, Ko KH, Kim WK, Kim DS, Chun W, Ali S, Kim HC.Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis. Neuroscience. 2005; 133(3): 715-727.

Shin EJ, Jhoo JH, Nabeshima T, Jhoo WK, Kwon MS, Lim YK, Chae JS, Jung ME, Park SJ, Jang KJ, Kim HC. Growth hormone releaser attenuates beta-amyloid (1 - 42)-induced memory impairment in mice. J Pharmacol Sci. 2005; 99(1):117-120.

Yoo BK, Choi JW, Han BH, Kim WK, Kim HC, Ko KH. Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia. Neurosci Lett. 2005 ; 376(3): 171-176.

Kim JH, Kim S, Yoon IS, Lee JH, Jang BJ, Jeong SM, Lee JH, Lee BH, Han JS, Oh S, Kim HC, Park TK, Rhim H, Nah SY. Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology. 2005; 48(5): 743-756.

Kim HC, Shin EJ, Jang CG, Lee MK, Eun JS, Hong JT, Oh KW. Pharmacological action of Panax ginseng on the behavioral toxicities induced by psychotropic agents. Arch Pharm Res. 2005; 28(9): 995-1001.

Hong JT, Kim HC, Kim HS, Lee YM, Oh KW. The role of nitric oxide on glutaminergic modulation of dopaminergic activation. Pharmacol Res. 2005; 52(4): 298-301.

Enomoto T, Noda Y, Mouri A, Shin EJ, Wang D, Murai R, Hotta K, Furukawa H, Nitta A, Kim HC, Nabeshima T.Long-lasting impairment of associative learning is correlated with a dysfunction of N-methyl-D-aspartate-extracellular signaling-regulated kinase signaling in mice after withdrawal from repeated administration of phencyclidine. Mol Pharmacol. 2005; 68(6): 1765-1774.

Lee BH, Jeong SM, Lee JH, Kim JH, Yoon IS, Lee JH, Choi SH, Lee SM, Chang CG, Kim HC, Han Y, Paik HD, Kim Y, Nah SY. Quercetin inhibits the 5-hydroxytryptamine type 3 receptor-mediated ion current by interacting with pre-transmembrane domain I. Mol Cells. 2005; 20(1): 69-73.

Kim JH, Park SM, Ha HJ, Moon CJ, Shin TK, Kim JM, Lee NH, Kim HC, Jang KJ, Wie MB. Opuntia ficus-indica attenuates neuronal injury in in vitro and in vivo models of cerebral ischemia. J Ethnopharmacol. 2006; 104(1-2): 257-262.

Park GH, Ryu JR, Shin CY, Choi MS, Han BH, Kim WK, Kim HC, Ko KH. Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes.Neurosci Res. 2006; 54(1): 15-23.

Lee JC, Cho GS, Choi BO, Kim HC, Kim YS, Kim WK. Intracerebral hemorrhage-induced brain injury is aggravated in senescence-accelerated prone mice. Stroke. 2006; 37(1): 216-222. Liu M, Sun A, Shin EJ, Liu X, Kim SG, Runyons CR, Markesbery W, Kim HC, Bing G. Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Eur J Neurosci. 2006; 23(8): 2027-2034.

Yamaguchi Y, Miyashita H, Tsunekawa H, Mouri A, Kim HC, Saito K, Matsuno T, Kawashima S, Nabeshima T. Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat. J Pharmacol Exp Ther. 2006; 317(3): 1079-1087.

Lee JH, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Park YS, Lee JH, Kim SS, Kim HC, Lee BY, Nah SY. Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes. Mol Cells. 2006 ; 21(1): 52-62.

Lee JH, Shin EJ, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Lee PH, Kim HC, Nah SY. Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2006; 536(1-2):5-92.

Yoo JH, Cho JH, Yu HS, Lee KW, Lee BH, Jeong SM, Nah SY, Kim HC, Lee SY, Jang CG.Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study. J Neurochem. 2006; 99(3): 976-988.

Zhang W, Shin EJ, Wang T, Lee PH, Pang H, Wie MB, Kim WK, Kim SJ, Huang WH, Wang Y, Zhang W, Hong JS, Kim HC. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB J. 2006; 20(14): 2496-2511.

Arimoto T, Choi DY, Lu X, Liu M, Nguyen XV, Zheng N, Stewart CA, Kim HC, Bing G. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 2007; 28(6): 894-906.

Shin EJ, Chae JS, Jung ME, Bing G, Ko KH, Kim WK, Wie MB, Cheon MA, Nah SY, Kim HC. Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor. Epilepsy Res. 2007; 73(3): 292-298.

Hunter RL, Dragicevic N, Seifert K, Choi DY, Liu M, Kim HC, Cass WA, Sullivan PG, Bing G.Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem. 2007; 100(5): 1375-1386.

Shin EJ, Nah SY, Chae JS, Bing G, Shin SW, Yen TP, Baek IH, Kim WK, Maurice T, Nabeshima T, Kim HC. Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.Neurochem Int. 2007; 50(6): 791-799.

Lee JH, Shin EJ, Jeong SM, Lee BH, Yoon IS, Lee JH, Choi SH, Kim YH, Pyo MK, Lee SM, Chae JS, Rhim H, Oh JW, Kim HC, Nah SY. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. Eur J Pharmacol. 2007; 564(1-3): 7-17.

Ma Y, Han H, Eun JS, Kim HC, Hong JT, Oh KW. Sanjoinine A isolated from Zizyphi Spinosi Semen augments pentobarbital-induced sleeping behaviors through the modification of GABA-ergic systems.Biol Pharm Bull. 2007; 30(9): 1748-1753.

Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Fukakusa A, Kumagai N, Kim HC, Nabeshima T, Takuma K, Yamada K. Activation of post-synaptic dopamine D(1) receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. J Neurochem. 2007; 103(6): 2589-2596.

Kim SD, Yang SI, Kim HC, Shin CY, Ko KH. Inhibition of GSK-3beta mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-kappaB in rat primary astrocyte. Brain Res. 2007; 1186: 12-20.

Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T, Kim HC. Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J Pharmacol Sci. 2007; 105(4): 367-371.

Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC, Yamada K. Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl). 2008; 196(2): 233-241.

Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim HC, Nabeshima T, Takuma K, Yamada K. Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. J Neurochem. 2008; 105(2): 436-444.

Shin EJ, Lee PH, Kim HJ, Nabeshima T, Kim HC.Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. J Pharmacol Sci. 2008; 106(1): 22-27. Shin EJ, Jeong JH, Bing G, Park ES, Chae JS, Yen TP, Kim WK, Wie MB, Jung BD, Kim HJ, Lee SY, Kim HC. Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice. Cell Signal. 2008; 20(4): 645-658.

Shin EJ, Ko KH, Kim WK, Chae JS, Yen TP, Kim HJ, Wie MB, Kim HC. Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats. Neurochem Int. 2008; 52(6): 1134-1147.

Lee JH, Lee BH, Choi SH, Yoon IS, Shin TJ, Pyo MK, Lee SM, Kim HC, Nah SY. Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation. Brain Res. 2008; 1203: 61-67.

Kim JY, Kim HC, Kim J, Lee J. Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM). Chem Pharm Bull (Tokyo). 2008; 56(7): 985-987.

Liu M, Hunter R, Nguyen XV, Kim HC, Bing G.Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment. J Neurosci Res. in press.

Shin EJ, Jeong JH, Kim AY, Koh YH, Nah SY, Kim WK, Ko KH, Kim HJ, Wie MB, Kwon YS, Yoneda Y, Kim HC. Protection Against Kainate Neurotoxicity By Ginsenosides: Attenuation Of Convulsive Behavior, Mitochondrial Dysfunction, and Oxidative Stress. J Neurosci Res. In press