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김현표 교수[Kim, Hyun Pyo]
hpkim@kangwon.ac.kr
033)250-6915
약품생화학반
염증발현기작 및 항염증제의 개발
· 1984~86, Florida AM대 약학대학 Post-Doc 연구원
· 1996, UC Davis 의과대학 방문교수
· 1999~2000, 약학대학장
· 2012~2015.2, 신약개발연구소장
· 1979, Seoul NationalUniversity (B.S - Pharmacy)
· 1981, KAIST ( M.S - Pharmaceutical Biochemistry)
· 1984, KAIST ( Ph.D. - Pharmaceutical Biochemistry)
· Inflamnation; biochemical aspect
· Development of anti-inflammatory drug
Kim, D. W., Son, K. H., Chang, H. W., Bae, K., Kang, S. S. and Kim, H. P.Anti-inflammatory activity of Sedum kamtschaticum. J. Ethnopharmacol. 90, 409-414 (2004).

Dao, T. T., Chi, Y. S., Kim, J., Kim, H. P., Kim, S., Park, H. Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives. Bioorg. Med. Chem. Lett. 14(5), 1165-1167 (2004).

Cho, J. Y., Park, J. S., Baik, K. U., Lee, J. G., Kim, H. P., Yoo, E. S., Park, M. H. Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relavant to rheumatoid arthritis. Pharmacol. Res. 49, 423-431 (2004).

Kim, J. S., Shin, S. H., Xu, Y. N., Kang, S. S., Son, K. H., Chang, H. W., Kim, H. P., Bae, K. Phenolic glycosides from Pyrola japonica. Chem. Pharm. Bull. 52(6), 714-717 (2004).

Byun, J. H., Kim, J. S., Kang, S. S., Son, K. H., Chang, H. W., Kim, H. P., Bae, K. Triterpenoid saponins from the roots of Sophora koreensis. Chem. Pharm. Bull. 52(7), 870-873 (2004).

Kim, H. P., Son K. H., Chang, H. W., Kang, S. S. Ati-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 96, 229-245 (2004).

Park, J. H., Son, K. H., Kim, S. W., Chang, H. W., Bae, K., Kang, S. S., Kim, H. P.Anti-inflammatory activity of Synurus deltoids. Phytotherapy Res. 18(11), 930-933 (2004).

Chi. Y. S., Kim, H. P. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostg. Leukot. Essent. Fatty Acids 72, 59-66 (2005).

Moon, T. C., Lin, C. X., Lee, J. S., Kim, D. S., Bae, K., Son, K. H., Kim, H. P., Kang, S. S., Chang, H. W. Antiinflammatory activity of astilbic acid from Astilbe chinensis. Biol. Pharm. Bull. 28(1), 24-26 (2005).

Han, C. K., Son, M. J., Chang, H. W., Chi, Y. S., Park, H., Kim, H. P. Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. Biol. Pharm. Bull. 28(8), 1366-1370 (2005).

Kim, J. S. Shim, S. S., Chae, S., Han, S. J., Kang, S. S., Son, K. H., Chang, H. W., Kim, H. P., Bae, K. Saponins and other constituents from the leaves of Aralia elata. Chem. Pharm. Bull. 53(6), 696-700 (2005).

Park, H., Dao, T. T., Kim, H. P.Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. Eur. J. Med. Chem. 40, 943-948 (2005).

Son, J. K., Son, M. J., Lee, E., Moon, T. C., Son, K. H., Kim, C-H., Kim, H. P., Kang, S. S., Chang,H. W. Ginkgetin, a biflavone from Ginkgo biloba leaves, inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Biol. Pharm. Bull. 28(12), 281-2184 (2005).

Lee, E., Haa, K., Yook, J. M., Jin, M. H., Seo, C. S., Son, K. H., Kim, H. P., Bae, K. H., Kang, S. S., Son, J. K., Chang, H. W. Antiasthmatic activity of an ethanol extract from Saururus chinesis. Biol. Pharm. Bull. 29(2), 211-215 (2006).

Chen, J., Chang, H. W., Kim, H. P., Park, H. Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg. Med. Chem. Lett. 16, 2373-2375 (2006).

Lim, H., Son, K. H., Chang, H. W., Kang, S. S., Kim, H. P.Effect of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol. Pharm. Bull. 29(5), 1046-1049 (2006).

Suh, S-J., Chung, T-W., Son, M-J., Kim, S-H., Moon, T. C., Son, K. H., Kim, H. P.,Chang, H. W., Kim, C-H. The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNONS expression, whish is mediated by ERK1/2 via NF-kB regulation, in RAW 264.7 cells. Arch. Biochem. Biophys. 447, 136-146 (2006).

Jin, M. H., Yook, J., Lee, E., Lin C. X., Quan, Z., Son, K. H., Kim, H. P., Kang, S. S., Chang, H. W. Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. Biol. Pharm. Bull. 29(5), 884-888 (2006).

Park, H., Kim, Y. H., Chang, H. W., Kim, H. P. Anti-inflammatory activity of synthetic C-C biflavonoids. J. Pharm. Pharmacol. 58, 1661-1667 (2006).

Moon, T. C., Hwang, H. S., Quan, Z., Son, K. H., Kim, C-H., Kim, H. P., Kang, S. S., Son, J. K., Chang, H. W. Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. Biol. Pharm. Bull. 29(12), 2359-2361 (2006).

Kim, Y. H., Kim, J., Park, H., Kim, H. P. Anti-inflammatory activity of synthetic chalcone derivatives: Inhibition of inducible nitric oxide synthase-catalyzed nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells. Biol. Pharm. Bull. 30(8), 1450-1455 (2007).