강원대학교 약학대학
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안성훈 교수[Ahn, Sung-Hoon]
ahnsh@kangwon.ac.kr
033)250-6912
약제학
약제학, 약동력학, 약물대사, 약물수송
· 2004.03-2005.09, 서울대학교 종합약학연구소 (선임연구원)
· 2005.10-2009.04, Laboratory of Metabolism, 미국 NCI/NIH (박사후연구원)
· 2009.05-2012.12, 한국화학연구원 신약플랫폼기술팀 (선임연구원)
· 2013.01-2015.02, 한국화학연구원 신약플랫폼기술팀 (책임연구원)
· 2014.03-2015.02, 과학기술연합대학원대학교 (UST), 의약 및 약품화학과 (교수)
· 2015.03-현재, 강원대학교 약학대학
· 1992.3-1996.2, 서울대학교 약학대학 제약학과 (약학사)
· 1996.3-1998.2, 서울대학교 대학원 약학과 (약제학 전공) (약학석사)
· 1998.3-2004.2, 서울대학교 대학원 약학과 (약제과학 전공) (약학박사)
· 신약개발을 위한 약동학 연구 (In vivo and in vitro pharmacokinetic study for a new drug discovery)
· 약물성 평가 연구 (Evaluation of drug-like properties (PhysChem & ADME/Tox) for hit-to-lead optimization)
· 약물대사와 수송에 관한 연구 (Metabolism and transport study of drugs, bile acids, and endogenous hormones)
· 질병모델에서의 약동력학 연구 (Pharmacokinetic/Pharmacodynamic (PK/PD) study in disease animal models)
· 약물상호작용 연구 (Drug-drug interaction and drug-endogenous compounds interactions)
· 약물대사체 규명 및 프로파일링 (Drug metabolites profiling and identification)
· LC-MS/MS를 이용한 생체시료에서의 약물분석 및 대사체학 연구 (Drug analysis and metabolomics study using LC-MS/MS)
Song KH, An HM, Kim HJ, AhnSH, Chung SJ, Shim CK. Simple liquid chromatography-electrospray ionization mass spectrometry method for the routine determination of salmon calcitonin in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Aug 5;775(2):247-55.

Ahn SH, Jeon SH, Tsuruo T, Shim CK, Chung SJ. Pharmacokinetic characterization of dehydroevodiamine in the rat brain. J Pharm Sci. 2004 Feb;93(2):283-92.

Koo TS, Kim DH, AhnSH, Kim KP, Kim IW, Seo SY, Suh YG, Kim DD, Shim CK, Chung SJ. Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism. J Pharm Sci. 2005 Oct;94(10):2187-97.

Ahn SH, Maeng HJ, Koo TS, Kim DD, Shim CK, Chung SJ. Quantification of clotiazepam in human plasma by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 13;834(1-2):128-33.

Sung JH, Hong SS, AhnSH, Li H, Seo SY, Park CH, Park BS, Chung SJ. Mechanism for increased bioavailability of tacrine in fasted rats. J Pharm Pharmacol. 2006 May;58(5):643-9.

Kim KP, AhnSH, Sung JH, Koo TS, Byun MJ, Kim DD, Shim CK, Chung SJ. Application of a sample pooling method for the accelerated assessment of the rate of uptake of drugs by the brain in rats. J Pharm Pharmacol. 2006 Jun;58(6):837-46.

Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res. 2007 Dec;48(12):2664-72.

Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 2008 Jul;14(7):908-20.

Cho JY, Kang DW, Ma X, Ahn SH, Krausz KW, Luecke H, Idle JR, Gonzalez FJ. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation, J Lipid Res. 2009; 50(5):924-37.

Yu KH, Lee YR, AhnSH, Kim DD, Shim CK, Chung SJ. Contribution of a significant first-pass effect of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in the liver to its poor bioavailability in rats. J Pharm Pharmacol. 2009 Sep;61(9):1197-203.

Kim SH, Ramu R, Kwon SW, Lee SH, Kim CH, Kang SK, Rhee SD, Bae MA, Ahn SH, Ha DC, Cheon HG, Kim KY, Ahn JH. Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1065-9.

Cho JY, Matsubara T, Kang DW, Ahn SH, Krausz KW, Idle JR, Luecke H, Gonzalez FJ. Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. J Lipid Res. 2010 May;51(5):1063-74.

Lee GN, Kim KR, Ahn SH, Bae MA, Kang NS. Discovery of cannabinoid-1 receptor antagonists by virtual screening. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5130-2.

Choi MK, Jin QR, AhnSH, Bae MA, Song IS. Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters. Xenobiotica. 2010 Dec;40(12):817-25.

Kim MS, Song JS, Roh H, Park JS, Ahn JH, Ahn SH, Bae MA. Determination of a peroxisome proliferator-activated receptor gamma agonist, 1-(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (KR-62980) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2011 Jan 5;54(1):121-6.

Song JS, Rho HJ, Park JS, Kim MS, Lee BH, Seo JW, Jeon DJ, Cheon HG, Ahn SH, Kwon KI, Bae MA. Preclinical pharmacokinetics of PDE-310, a novel PDE4 inhibitor. Drug Metab Pharmacokinet. 2011;26(2):192-200.

Kim SH, Kwon SW, Chu SY, Lee JH, Narsaiah B, Kim CH, Kang SK, Kang NS, Rhee SD, Bae MA, Ahn SH, Ha DC, Kim KY, Ahn JH. Identification of cyclicsulfonamide derivatives with an acetamide group as 11b hydroxysteroid dehydrogenase 1 inhibitors, Chem Pharm Bull (Tokyo). 2011;59(1):46-52.

Choi MK, Jin QR, Choi YL, Ahn SH, Bae MA, Song IS. Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions. Biopharm Drug Dispos. 2011 Apr;32(3):175-84.

Kim MS, Park JS, Jang SM, Lee BH, Ahn SH, Ahn JH, Yoo SE, Song IS, Silinski P, Schneider SE, Bae MA. Determination of a dipeptidyl peptidase IV agonist, β-aminoacyl containing thiazolidine derivatives (KR-66223) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2011 Jul; 55(5): 1083-8.

Song JS, Chae JW, Lee KR, Lee BH, Choi EJ, Ahn SH, Kwon KI, Bae MA. Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. Xenobiotica. 2011 Oct;41(10):895-902.

Park JS, Kim MS, Song JS, Choi SH, Lee BH, Woo J, Ahn JH, Bae MA, Ahn SH*. Dose-Independent Pharmacokinetic Profiling of a New Peroxisome Proliferator-Activated Receptor g agonist, KR-62980, in SD Rats and ICR Mice. Arch Pharm Res, 2011 34(12): 2051-8.

Kim SH, Bok JH, Lee JH, Kim IH, Kwon SW, Lee GB, Kang SK, Park JS, Jung WH, Kim HY, Rhee SD, Ahn SH, Bae MA, Ha DC, Kim KY, Ahn JH. inhibitors, ACS Med Chem Lett. 2012;3(2):88-93.

Han SY, Lee CO, Ahn SH, Lee MO, Kang SY, Cha HJ, Cho SY, Ha JD, Ryu JW, Jung H, Kim HR, Koh JS, Lee J. Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo. Invest New Drugs. 2012 Apr; 30(2):518-23.

Choi SH, Lee KR, Woo JC, Kim NJ, Moon DC, Hwang ES, Ahn SH, Bae MA, Kim MS. Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2012 Apr 7;63:47-52.

Song JS, Lee KR, Kwon HJ, Rhee SD, Kim MS, Choi SH, Lee SH, Song IS, Ahn JH, Ahn SH, Bae MA. Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor, Drug Metab Pharmacokinet. 2012 Apr 25;27(2):216-22.

Lee JH, Chae YJ, Lee KR, AhnSH, Seo JW, Jin QR, Woo YA, Lee GW, Cho SC, Kwon SW, Park DH. Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development. J Pharm Biomed Anal. 2012 Nov;70:587-91.

Park MJ, Lee KR, Shin DS, Chun HS, Kim CH, Ahn SH, Bae MA, Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests, Toxicol Lett, 2013 Jan 10; 216 (1):9-15.

Zheng Z, Lee BH, Choi JY, Ryu YH, Bae MA, AhnSH*, Determination of 5-HT receptor antagonists, MEFWAY and MPPF using liquid chromatography electrospray ionization tandem mass spectrometry in rat plasma and brain tissue, J Chromtogr B. 2013 Jan 15; 913-914:24-29.

Lee KR, Choi SH, Song JS, Kwak EY, Chae YJ, Im SH, Lee BH, Seo H, Cho WK, Kim MS, Kim NJ, Ahn SH, Bae MA. Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans. Xenobiotica. 2013 Feb;43(2):193-200.

Lee KR, Song JS, Chae YJ, Kim MS, Choi SH, Jeon DJ, Bae MA, Ahn SH*, Determination of 2-Aryl-7(3',4'-Dialkoxyphenyl)-Pyrazolo [1,5-alpha] Pyrimidine, a Novel Phosphodiesterase-4 Inhibitor, in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry, J Chromatogr Sci, 2013 Jul;51(6):517-23.

Lee KR, Choi SH, Song JS, Seo H, Chae YJ, Cho HE, Ahn JH, AhnSH, Bae MA. Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies. Biomed Chromatogr. 2013 Jul;27(7):846-52.

Ito S, Satoh J, Matsubara T, Shah YM, AhnSH, Anderson CR, Shan W, Peters JM, Gonzalez FJ. Cholestasis induces reversible accumulation of periplakin in mouse liver, BMC Gastroenterol. 2013 Jul 13;13(1):116.

Chanda D, Kim YH, Li T, Misra J, Kim DK, Kim JR, Kwon J, Jeong WI, AhnSH, Park TS, Koo SH, Chiang JY, Lee CH, Choi HS. Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH. PLoS One. 2013 Jul 22;8(7):e68845.

Lee JH, Ha JH, Park DH, Choi DR, Lee KW, Ahn SH*, Kim CY*, Quantification of Zabofloxacin in rat plasma using HPLC-UV detector and its application to a pharmacokinetic study, J Liq Chromatogr R T, 2014 Feb; 37:311-320.

Seo H, Choi SH, Kwak EY, Zheng Z, Kwak HJ, Ahn JH, Lee YM, Ahn SH, Bae MA, Song JS, Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl) phenyl) cyclohexyl) acetic acid (KR-69232) in rat plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study, Biomed Chromatogr. 2014 Mar;28(3):324-6.

Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM, Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis, Mol Cell Biol. 2014 Apr;34(7):1208-20.

Kwak EY, Im SH, Seo HY, Cho WK, Lee YL, Woo JC, Ahn S, AhnSH, Kwak HJ, Ahn JH, Bae MA, Song JS, Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor, Xenobiotica 2014 May;44(5):465-71.

Zheng Z, Song JS, Lee BH, AhnSH, Ahn JH, Woo J, Park JY, Yoo DS, Bae MA. Determination of 2-(3-Benzoyl)-4-Hydroxy-1,1-Dioxo-2H-1,2-Benzothiazine-2-yl-1-Phenylethanone by Liquid Chromatography-Tandem Mass Spectrometry. J Chromatogr Sci. 2014 May-Jun;52(5):406-12.

Im SH, Park MJ, Seo HY, Choi SH, Kim SK, AhnSH*, Determination of mesoridazine by liquid chromatography?tandem mass spectrometry and its application to pharmacokinetic study in rats, J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:117-23.

Song JH, Kim TH, Jung JW, Kim N, AhnSH, Hwang SO, Kang NS, Yoo SE, Koo TS, Quantitative determination of enzalutamide, an anti-prostate cancer drug, in rat plasma using liquid chromatography-tandem mass spectrometry, and its application to a pharmacokinetic study. Biomed Chromatogr. 2014 Aug;28(8):1112-7.

Lee JH, Jung KH, Lee H, Son MK, Yun SM, AhnSH, Lee KR, Lee S, Kim D, Hong S, Hong SS. HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy. Oncotarget. 2014 Oct 30;5(20):10180-97.

Zheng Z, Im SH, Lee BH, Seo H, Bae MA, AhnSH*, In vitro permeability analysis, pharmacokinetics and brain uptake of WAY-100635 and FCWAY in rats using liquid chromatography electrospray ionization tandem mass spectrometry, Arch Pharm Res, 2014 May 17. (in press).

Im SH, Ahn JH, Kim KY, Bae MA, Kim SK*, Ahn SH*, Pharmacokinetic characterization of KR-67500, a novel 11ß-HSD1 inhibitor, Yakhakhoeji, 2015 Apr; 59 (2) (in press)

Kwak EY, Im S, Byun BJ, Cheon HS, Chung HC, Shin SH, Bae MA, Ahn SJ, Chae JH, AhnSH*, A Novel Pharmacokinetic Approach to Establish the Feasibility of Zebrafish as an Animal Model for Drug Discovery and Development, RSC Advances, 2015 (under revision).
- 국내 특허 출원 및 등록 9 건, 해외 특허 출원 8 건
- 주요 특허 리스트
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