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양희정 교수[Yang, Heejung]
heejyang@kangwon.ac.kr
033)250-6919
천연물화학
천연물화학 (natural products chemistry)
· 2011.9-2013.10, 서울대학교 약학대학 종합약학연구소, 선임연구원
· 2013.11-2014.2, NIH/NCI, visiting fellow
· 2014-3-현재, 강원대학교 약학대학 약학과, 조교수
· 2006, Seoul National University (B.S. in pharmacy)
· 2008, Seoul National University (M.S. in pharmacognosy)
· 2011, Seoul National University (Ph.D. in pharmacognosy)
1. Isolation and structure elucidation of bioactive compounds from Korean native natural products
2. Screening of extracts and compounds from natural products on in vitro and in vivo models
3. Standardization of herbal drugs using hyphenated techniques such as LC-MS, GC-MS, LC-DAD
1. Yang H, Moon E, Choi M, Kim JY, Kim SO, Yoo YH, Sung SH. 2013. Complete 1H and 13C NMR spectral analysis of the pairs of 20(S) and 20(R)-ginsenosides. J Ginseng Res. (accepted)

2. Yang H, Lee DY, Jeon M, Suh Y, Sung SH. 2013. Simultaneous Determination of Five Active Compounds in Artemisia princeps and A. capillaris based on UPLC-DAD and Discrimination of Two Species with Multivariate Analysis. Arch. Pharm. Res. (in press)

3. Cho N, Yang H, Lee M, Huh J; Kim HW, Kim HP, Sung SH. 2013. Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells. J Nat Prod. 76(12):2291-7.

4. Lee M, Lee SH, Kang J, Yang H, Jeong EJ, Kim HP, Kim YC, Sung SH. 2013. Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP1c dependent pathway. Molecules. 18(9) L10484-96.

5. Yang H, Kim HS, Jeong EJ, Khiev P, Chin Y, Sung SH. 2013. Plant-derived juvenile hormone III analogues from the stem barks of Cananga latifolia. Phytochemistry. 94:277-83.

6. Cho N, Lee KY, Huh J, Choi JH, Yang H, Jeong EJ, Kim HP, Sung SH. 2013. Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. Food Chem. Toxicol. 58:355-61.

7. Yang H, Lee S, Sung SH, Kim J, Kim YC. 2013. Neuroprotective compounds from twigs of Salix pseudo-lasiogyne and their anti-amnesic effects on scopolamine-induced memory deficit in mice. Planta Med. 79(1):78-82.

8. Yang H, Yoo G, Kim HS, Kim JY, Kim SO, Yoo YH, Sung SH. 2012. Implication of the stereoisomers of ginsenoside derivatives in anti-proliferative effect of HSC-T6 cells. J. Agric. Food Chem. 60(47):11759-64.

9. Nhiem NX, Lee HY, Kim NY, Park SJ, Kim ES, Han JE, Yang H, Kim SH. 2012. Stereochemical assignment of five new lignan glycosides from Viscum album by NMR study combined with CD spectroscopy. Magn. Reson. Chem. 50(11):772-7.

10. Cho N, Choi JH, Yang H, Jeong EJ, Lee KY, Kim YC, Sung SH. 2012. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food Chem. Toxicol. 50(6):1940-5.

11. Yang H, Cho HJ, Sim SH, Chung YK, Kim DD, Sung SH, Kim J, Kim YC. 2012. Cytotoxic terpenoids from Juglans sinensis leaves and twigs. Bioorg. Med. Chem. Lett. 22(5):2079-83.

12. Jeong EJ, Seo H, Yang H, Kim J, Sung SH, Kim YC. 2012. Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells. J. Enzyme Inhib. Med. Chem. 27(6):875-9.

13. Jeong EJ, Kim TB, Yang H, Kang SY, Kim SY, Sung SH, Kim YC. 2012. Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells. Phytomedicine. 19(3-4):317-21.

14. Cho N, Huh J, Yang H, Jeong EJ, Kim YC, Kim J, Sung SH. 2012. Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. J. Enzyme Inhib. Med. Chem. 27(1):1-4.

15. Jeong EJ, Yang H, Kim SH, Kang SY, Sung SH, Kim YC. 2011. Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells. Food Chem. Toxicol. 49(6):1394-8.

16. Yang H, Jeong EJ, Kim J, Sung SH, Kim YC. 2011. Antiproliferative triterpenes from the leaves and twigs of Juglans sinensis on HSC-T6 cells. J. Nat. Prod. 74(4):751-6.

17. Yang H, Sung SH, Kim J, Kim YC. 2011. Neuroprotective diarylheptanoids from the leaves and twigs of Juglans sinensis against glutamate-induced toxicity in HT22 cells. Planta Med. 77(8):841-5.

18. Yang H, Cho YW, Kim SH, Kim YC, Sung SH. 2010. Triterpenoidal saponins of Pulsatilla koreana roots. Phytochemistry. 71(16):1892-9.

19. Yang H, Yoon KD, Chin YW, Kim YC, Kim J. 2010. The isolation of acetylcholinesterase inhibitory constituents from Lycoris radiata using On-line HPLC-biochemical detection system. Nat. Prod. Sci. 16(4):228-232.