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조현종 교수[Cho, Hyun-Jong]
hjcho@kangwon.ac.kr
033)250-6916
약물전달시스템
약물전달시스템 (Drug Delivery Systems)
· 2011.3~2012.2, 서울대학교 약학대학 종합약학연구소, 선임연구원
· 2012.3~2012.8, 순천대학교 약학대학 약학과, 전임강사/조교수
· 2012.8~현재, 강원대학교 약학대학 약학과 조교수
· 2006, Seoul National University (B.S. in Pharmacy)
· 2011, Seoul National University (Ph.D. in Pharmaceutics)
· Tumor-targeted drug delivery and in vivo imaging systems
· Mucosal (respiratory and oral routes) drug delivery systems
· Biomacromolecule (proteins and nucleic acids) therapeutics
· Development of multifunctional biopolymer-based nanoparticulate systems
1. Lin, H., Li, H., Cho, H.J., Bian, S., Roh, H.J., Lee, M.K., Kim, J.S., Chung, S.J., Shim, C.K., Kim, D.D. 2007. Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies. J Pharm Sci 96, 341-350.

2. Huh, Y., Cho, H.J., Yoon, I.S., Choi, M.K., Kim, J.S., Oh, E., Chung, S.J., Shim, C.K., Kim, D.D. 2010. Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride. Eur J Pharm Sci 40, 9-15.

3. Piao, H.M., Balakrishnan, P., Cho, H.J., Kim, H., Kim, Y.S., Chung, S.J., Shim, C.K., Kim, D.D. 2010. Preparation and evaluation of fexofenadine microemulsions for intranasal delivery. Int J Pharm 395, 309-316.

4. Cho, H.J., Balakrishnan, P., Shim, W.S., Chung, S.J., Shim, C.K., Kim, D.D. 2010. Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron-cyclodextrin complex and carboxymethylcellulose for intranasal delivery. Int J Pharm 400, 59-65.

5. Cho, H.J., Balakrishnan, P., Park, E.K., Song, K.W., Hong, S.S., Jang, T.Y., Kim, K.S., Chung, S.J., Shim, C.K., Kim, D.D. 2011. Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride. J Pharm Sci 100, 681-691.

6. Cho, H.J., Choi, M.K., Lin, H., Kim, J.S., Chung, S.J., Shim, C.K., Kim, D.D. 2011. Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by air-liquid interface method for nasal drug transport study. J Pharm Pharmacol 63, 385-391.

7. Cho, H.J., Balakrishnan, P., Chung, S.J., Shim, C.K., Kim, D.D. 2011. Evaluation of protein stability and in vitro permeation of lyophilized polysaccharides-based microparticles for intranasal protein delivery. Int J Pharm 416, 77-84.

8. Cho, H.J., Yoon, H.Y., Koo, H., Ko, S.H., Shim, J.S., Lee, J.H., Kim, K., Kwon, I.C., Kim, D.D. 2011. Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel. Biomaterials 32, 7181-7190.

9. Ku, W.S., Cho, H.J., Yoon, I.S., Kim, J.H., Cha, B.J., Kim, J.S., Kim, K.M., Kang, S.K., Chung, S.J., Shim, C.K., Kim, D.D. 2011. Rapid and sensitive determination of udenafil in plasma by LC-MS/MS for intranasal pharmacokinetic study in rats. Chem Pharm Bull 59, 1083-1088.

10. Yoon, I.S., Chung, C.W., Sung, J.H., Cho, H.J., Kim, J.S., Shim, W.S., Shim, C.K., Chung, S.J., Kim, D.D. 2011. Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold. J Biosci Bioeng 112, 402-408.

11. Cho. H.K., Cho, H.J., Lone, S., Kim, D.D., Yeum, J.H., Cheong, I.W., 2011. Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy. J Mater Chem 21, 15486-15493.

12. Chung, C.W., Kang, J.Y., Yoon, I.S., Hwang, H.D., Balakrishnan, P., Cho, H.J., Chung, K.D., Kang, D.H., Kim, D.D. 2011. Interpenetrating polymer network (IPN) scaffolds of sodium hyaluronate and sodium alginate for chondrocyte culture. Colloids Surf B Biointerfaces 88, 711-716.

13. Cho, H.J., Yoon, I.S., Yoon, H.Y., Koo, H., Jin, Y.J., Ko, S.H., Shim, J.S., Kim, K., Kwon, I.C., Kim, D.D. 2012. Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin. Biomaterials 33, 1190-1200.

14. Cho, H.J.*, Ku, W.S.*, Termsarasab U., Yoon, I.S., Chung, C.W., Moon, H.T., Kim, D.D., 2012. Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations. Int J Pharm 423, 153-160 (*equally contributed).

15. Hwang, H.D., Cho, H.J., Balakrishnan, P., Chung, C.W., Yoon, I.S., Oh, Y.K., Byun, Y., Kim, D.D. 2012. Cross-linked hyaluronic acid?based flexible cell delivery system: Application for chondrogenic differentiation. Colloids Surf B Biointerfaces 91, 106-113.

16. Yang, H., Cho, H.J., Shim, S.H., Chung, Y.K., Kim, D.D., Sung, S.H., Kim, J., Kim, Y.J., 2012. Cytotoxic terpenoids from Juglans sinensis leaves and twigs. Bioorg Med Chem Lett 22, 2079-2083.

17. Cho, H.J., Chong, S., Chung, S.J., Shim, C.K., Kim, D.D., 2012. Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: Its application for head and neck cancer treatment. Pharm Res 29, 1007-1019.

18. Balakrishnan, P., Song, C.K., Cho, H.J., Yang, S.G., Kim, D.D., Yong, C.S., Choi, H.G., 2012. Inclusion complex effect on the bioavailability of clotrimazole from poloxamer-based solid suppository. Arch Pharm Res 35, 1169-1175.

19. Cho, H.J., Yoon, H.Y., Koo, H., Ko, S.H., Shim, J.S., Cho, J.H., Park, J.H., Kim, K., Kwon, I.C., Kim, D.D., 2012. Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobe for cancer diagnosis. J Control Release 162, 111-118.

20. Yoon, I., Han, S.Y., Choi, Y.H., Kang, H.E., Cho, H.J., Kim, J.S., Shim, C.K., Chung, S.J., Chong, S., Kim, D.D. Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats. Xenobiotica (in press).

21. Doh, H.J., Jung, Y., Balakrishnan, P., Cho, H.J.*, Kim, D.D.* A novel lipid nanoemulsion system for improved permeation of granisetron. Colloids Surf B Biointerfaces (in press) (*co-corresponder)

22. Jin, Y.J., Termsarasab, U., Ko, S.H., Shim, J.S., Chong, S., Chung, S.J., Shim, C.K., Cho, H.J.*, Kim, D.D.* Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma. Pharm Res (in press) (* co-corresponder)